(9H) Tetra 4-Hydroxy Carbozoline

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(9H) Tetra 4-Hydroxy Carbozoline

Norepinephrine stimulates the nerves that control the muscles of the heart by binding to the β1- and β2-adrenergic receptors. Carvedilol blocks the binding to those receptors, which both slows the heart rhythm and reduces the force of the heart's pumping.

This lowers blood pressure thus reducing the workload of the heart, which is particularly beneficial in heart failure patients. Norepinephrine also binds to the α1-adrenergic receptors on blood vessels, causing them to constrict and raise blood pressure.

Carvedilol blocks this binding to the α1-adrenergic receptors too, which also lowers blood pressure.

 

Applications : Carvedilol

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